| publication name | The study of long noncoding RNA TUG 1 and ZEB2‑AS1 expression in newly diagnosed Egyptian adult acute myeloid leukemia patients |
|---|---|
| Authors | Amira Mohamed Noureldin Abdelrahman1 , Safa Mohammed Diab1 , Howyda Moh. Kamal Shabaan1 , Mai Nasser Abdelmomen Ahmed1* and Reem Nabil2 |
| year | 2023 |
| keywords | |
| journal | |
| volume | Not Available |
| issue | Not Available |
| pages | Not Available |
| publisher | Not Available |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background The hematopoietic malignancy acute myeloid leukemia is a fatal disease with poor clinical prognoses. Long non-coding RNA taurine-upregulated gene1 (lncRNA TUG1) and zinc fnger E-box binding homeobox 2 antisense RNA1 (lncRNA ZEB2-AS1) are reported to participate in the development and progression of diferent types of malignancies. The goal of the current study was to evaluate the prognostic value of the lncRNAs TUG1 and ZEB2-AS1 as well as their various expression patterns in newly diagnosed Egyptian adult acute myeloid leukemia patients. Methods We assessed the expression levels of both lncRNA TUG1 and lncRNA ZEB2-AS1 using the quantitative real-time reverse transcription polymerase chain reaction technique (qRT-PCR) in 80 newly diagnosed AML patients and 20 healthy subjects. Results lncRNA TUG1 expression was signifcantly higher in the AML cases compared to the controls (P