A field experiment was carried out during the two successive seasons of 2011/2012 and 2012/2013 in private farm at El–Dair village, Kalubia governorate in sandy soil, to investigate the effect of foliar spray with some safety compound (Borka vit, Vitamin-X and Chitosan) on growth, productivity and quality of some Strawberry cultivars, i.e., Sweet Charlie, Florida and Festival. This experiments included 12 treatments resulted from the interaction between three cultivars and four safety compound treatments. Obtained results showed that, there were significant differences among the studied strawberry cultivars in all measured vegetative growth traits, fruit yield and its components as well as fruit quality. In this respect, cv. Florida reflected the highest values of early yield. Also, safety compounds-sprayed plants showed its superiority in enhancing the vegetative growth, total produced fruit yield and its components as well as fruit quality. In addition, using Borka vit at 3 g/l followed by Vitamin-X at 0.75cm3/l reflected the highest values in all studied growth and yield traits of tested cultivars. Spraying plants of cv. Festival with Borka vit produced fruits with highest values of TSS and vitamin-c in the two seasons. Thereby, it could be recommended that foliar application with some safety compounds (Borka vit, Vitamin-X and Chitosan) could be used to improve growth, productivity and quality of some Strawberry cultivars. Keywords: Strawberry, cv. Sweet Charlie, Festival, Florida, Borka vit, Vitamin-X, Chitosan, Vegetative growth, fruit yield, fruit quality.