Staff Members - Benha University
SERUM PROLACTIN LEVEL AS A BIOLOGICAL MARKER OF SEVERITY IN LIVER CIRRHOSIS
International Journal of Development Research • 2017
Publication Information
Authors
1Ramy a. Metwally, 1Mahmoud Rizk and 2,*Mohamed Ali Awadein
Keywords
AFP, Hepatocellular Carcinoma,
Gene expression,
Cirrhosis,
Golgi protein 73
Journal
International Journal of Development Research
Publisher
Copyright ©2017, Ramy a. Metwally et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly c
Volume
Vol. 07
Issue
Issue, 08
Pages
14787-14791
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background: Cirrhosis of the liver is a chronic disease that involves the whole organ. In liver
cirrhosis the gonadal axis is affected. Hyperprolactinemia is often present in these patients as well
as hyperestrogenemia, both are responsible for the clinical characteristics of feminization.
Patients and Methods: We investigated 50 patients with cirrhosis. The diagnosis of cirrhosis
was based on biochemical evidence and clinical diagnosis including ascites or encephalopathy.
Also prognostic indices (Child-Pugh) and prolactin levels are assessed.
Results: Mean age was 51.94±5.99. Mean Child-Pugh score was 9.16±3.16. Mean prolactin
levels were 18.76±9.14 ng/ml. Patients with hepatic encephalopathy compared with patients
without encephalopathy had significantly higher levels of prolactin. Prolactin levels were also
significantly related to ascites degree. In regression analysis prolactin level was significantly
dependent on Child-Pugh score.
Conclusions: Prolactin level increases significantly with severity of liver disease particularly in
patients with ascites and hepatic encephalopathy. High prolactin level could therefore be
considered as a negative prognostic marker of liver cirrhosis.
cirrhosis the gonadal axis is affected. Hyperprolactinemia is often present in these patients as well
as hyperestrogenemia, both are responsible for the clinical characteristics of feminization.
Patients and Methods: We investigated 50 patients with cirrhosis. The diagnosis of cirrhosis
was based on biochemical evidence and clinical diagnosis including ascites or encephalopathy.
Also prognostic indices (Child-Pugh) and prolactin levels are assessed.
Results: Mean age was 51.94±5.99. Mean Child-Pugh score was 9.16±3.16. Mean prolactin
levels were 18.76±9.14 ng/ml. Patients with hepatic encephalopathy compared with patients
without encephalopathy had significantly higher levels of prolactin. Prolactin levels were also
significantly related to ascites degree. In regression analysis prolactin level was significantly
dependent on Child-Pugh score.
Conclusions: Prolactin level increases significantly with severity of liver disease particularly in
patients with ascites and hepatic encephalopathy. High prolactin level could therefore be
considered as a negative prognostic marker of liver cirrhosis.