Objective: To compare the effect of intraperitoneal lidocaine installation to that of intravenous lidocaine injection on post-operative pain and analgesic requirements,in patients who were undergoing cesarean section. STUDY DESIGNE: Cross-sectional,Populations of the study were comprised of 150 pregnant full term female, going to have cesarean section. Patients have been randomized into 3 groups 1st group A (n=50 women): distilled water was given both intraperitoneally and intravenously during caesarean section. 2nd group B (n=50 women): received intraperitoneal instillation of lidocaine and intravenous distilled water injection. 3rd group C ( n= 50 women): received intravenous lidocaine injection and intraperitoneal instillation of distilled water . Results: There was statistically highly significant difference between group B and C compared to control group as regard visual analogue scale , total pethidine consumption and time of ambulation . The statistical analysis: Results are expressed as mean ± standard deviation (SD). The collected data were tabulated and analyzed by suitable statistical methods as one way Anova test for comparison between the mean values of different variables in the three groups , and using chisquare test for comparison of qualitative values . SPSS computer program (version 12 windows) was used for data analysis. Conclusion: We concluded that lidocaine administration either intravenously or intraperitoneally during caesarean section under general anesthesia provided a significant degree of analgesia as shown by smaller pain scale and reduction in pethidine consumption and early ambulation. Intravenous administration of lidocaine is as effective as intraperitoneal instillation for reducing pain and pethidine consumption, and also much easier and universally applicable regardless of intra-abdominal condition compared to that of intraperitoneal instillation.