Objectives: Preeclampsia is associated with significant morbidity and mortality especially in
high-risk groups. Impairment of endogenous nitric oxide has been shown to be associated with
the disease and prophylactic therapy may ameliorate this condition and improve pregnancy
outcome. This study valuated nitric oxide donors prophylactic treatment for preeclampsia in
high-risk teenage primigravidae.
Methods: The study included three hundred primigravidae aged20 years with singleton
pregnancy. Abdominal pulsed color Doppler ultrasound was done at 24 weeks gestation and
pregnancies with uterine artery diastolic notch were randomly allocated to a control group
received placebo vaginal tablets and a study group received isosorbid mononitrate 20mg
tablet once daily applied vaginally until delivery.
Outcomes: Incidence of preeclampsia and maternal, fetal, and neonatal outcome in both
groups.
Results: The study group had significant lower incidence of preeclampsia, preterm birth,
intrauterine growth restriction and of neonatal admission to the intensive care (p50.05).
Conclusions: Nitric oxide donors prophylactic treatment for preeclampsia in high-risk teenage
pregnancies decrease the incidence of preeclampsia and improve maternal, fetal, and neonatal
outcomes. Further studies on larger sample size are required to confirm these results.