Staff Members - Benha University
Obesity in Relation to Ovarian Response in IVF Treatment
• 2022
Publication Information
Authors
Howaida Hashim1, Mahmoud Gehad2, Badawi Khalid2, Fahad Al Salman1, Samar Hassan1,
Afaf Felemban1, Haya Al Fozan1, M. Al Bugnah1
Keywords
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Journal
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Publisher
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Issue
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Pages
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publication.type
Local
Paper Link
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Supplementary Materials
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Abstract
ntroduction: The effect of Body Mass Index (BMI), which reflects the
woman’s obesity, in IVF treatment cycle, remains unclear. In 1997, the
World Health Organization (WHO) provided authoritative refinements to
the overweight terminology and BMI cutoffs [1]. Objective: To verify the
relationship between BMI and ovarian response in IVF treatment cycle. Design: Retrospective study. Materials & Methods: The study includes 2625
IVF treatment cycles performed in our IVF center in the period of 4 years.
Patients were divided into five groups using the WHO criteria according to
their BMI [2]. Cancellation rate, mean last E2 before hCG administration,
mean endometrial thickness, mean duration of stimulation, number of eggs
retrieved, fertilization rate, pregnancy and abortion rates were analyzed. The
unpaired t-test was used in statistical analysis. Results: There was statistically significant less mean oestradiol level prior to hCG, less endometrial
thickness and less number of simulation days as BMI gets higher. In contrast, there was a positive relationship between cancellation rate and higher
BMI except with BMI >39 which was not, possibly due to lower number of
patients available. But if we look at the cause of cancellation it was 100% due
to insufficient number of follicles obtained for this group (BMI >39). Also,
days of stimulation are significantly lower for the same group of patients in
comparison with the other groups. Retrieval, fertilization and pregnancy
rates were not significant between all groups. Abortion rate gets significantly higher as BMI increased. Conclusion:
woman’s obesity, in IVF treatment cycle, remains unclear. In 1997, the
World Health Organization (WHO) provided authoritative refinements to
the overweight terminology and BMI cutoffs [1]. Objective: To verify the
relationship between BMI and ovarian response in IVF treatment cycle. Design: Retrospective study. Materials & Methods: The study includes 2625
IVF treatment cycles performed in our IVF center in the period of 4 years.
Patients were divided into five groups using the WHO criteria according to
their BMI [2]. Cancellation rate, mean last E2 before hCG administration,
mean endometrial thickness, mean duration of stimulation, number of eggs
retrieved, fertilization rate, pregnancy and abortion rates were analyzed. The
unpaired t-test was used in statistical analysis. Results: There was statistically significant less mean oestradiol level prior to hCG, less endometrial
thickness and less number of simulation days as BMI gets higher. In contrast, there was a positive relationship between cancellation rate and higher
BMI except with BMI >39 which was not, possibly due to lower number of
patients available. But if we look at the cause of cancellation it was 100% due
to insufficient number of follicles obtained for this group (BMI >39). Also,
days of stimulation are significantly lower for the same group of patients in
comparison with the other groups. Retrieval, fertilization and pregnancy
rates were not significant between all groups. Abortion rate gets significantly higher as BMI increased. Conclusion: