Out of the examined livers of some farm animals (1000 sheep, 825 cattle, 1740 buffaloes and 1360 camels) of different ages and sexes slaughtered at abattoirs in Cairo, Giza and Kalubia provinces, during the period from January 2011 to March 2013, the incidence of the bacterial affections was 5%, 3.03%, 1.29% and 1.91% , respectively. Bacteriological examination revealed that Staphylococcus aureus, Corynebacterium pyogenes and Escherichia coli were the most common aerobic bacteria while Clostridium perfringens and Fusobacterium necrophorum were the most common anaerobic bacteria isolated from the affected livers. Corynebacterium ovis was isolated from six cases of sheep. Histopathologically, suppurative hepatitis was the commonest lesion usually in the form of abscesses. Coagulative necrosis was noticed in cases where anaerobes were isolated. KEY WORDS: Bacterial affections, Farm animals, Staph. aureus, Coryne. pyogenes, E.coli, Histopatholog, Hepatitis.