Were to evaluate serum level of FMS-like Tyrosine Kinase-1 (Flt-1) as a diagnostic utility in pre-eclampsia and its correlation to the severity of the disease, as well as the effect of antioxidant of vitamin E to this level. 20 normotensive pregnancies, 40 Extreme pre-eclamptic tolerant Furthermore 20 gentle pre-eclamptic patients, serum focuses of sFlt-1 Furthermore vitamin e were evaluated with the elisa system. Serum sFlt-1 level (825. 7 ±70. 0 ng/l) might have been altogether higher over those gentle preeclamptic aggregation (617. 2 ±58. 4 ng/l) Also both were higher over the normotensive assembly (475. 7 ±29. 1). Vitamin e level might have been altogether easier in the extreme preeclamptic assembly (0. 31 ±0. 18 mg/dl) over gentle preeclamptic aggregation (1. 00 ±0. 26 mg/dl) Also both were more level over normotensive gathering (2. 01 ±0. 26). In the preeclampsia group, there might have been An negative correspondence the middle of FMS in tyrosine kinase What's more vitamin e (rho= -0. 557 and p=