Rationale: Automated drug dispensers have replaced floor stocks and medication cabinets in all hospital areas. Anaesthesia workstations have been proven to be particularly challenging owing to the critical patients under their care and the nature of the medications they administer. Aims and objectives: To understand how well anaesthesia personnel accept an automated drug dispenser cabinet (ADC) as an anaesthesia workstation and investigate its effect on drug management and costs in the operating room (OR). Methods: We used mixed methods. The first part consisted of a cross-sectional study evaluating anaesthesia staff satisfaction with the ADC using a questionnaire based on the technology acceptance model (TAM). Second, we analysed the expenditure of five commonly used anaesthetic medications by the OR before and after the introduction of the ADC. Results: We received 63 responses from 96 anaesthesia department employees, giving us a 65.6% response rate. There was a significant positive relationship between perceived usefulness (PU), perceived ease of use (PEOU), and technology acceptance (TA) (p