The aim of this study was undertaken to evaluate the effect of nursing intervention on pelvic organ prolapse symptoms. Design: A quasi experimental design was utilized to fulfill the aim of this study. Setting: The study was conducted at gynecological outpatient clinic affiliated to Benha University Hospital. Sample: A purposive sample of 45 women recruited in the study according to inclusion criteria. Tools: Four tools were used for data collection; a structured interviewing questionnaire, women' compliance toward recommended nursing instructions sheet, pelvic organ prolapse symptom score and pelvic organ prolapse impact questionnaire. Results: There was a significant improvement in women' knowledge and compliance regarding pelvic organ prolapse (p˂0.000). Additionally, mean scores of pelvic organ prolapse symptoms and pelvic organ prolapse impact questionnaire after one month and three months remarkably reduced compared to before nursing intervention (p˂0.000). Conclusion and recommendation: Nursing intervention was effective in improving women' knowledge and compliance regarding pelvic organ prolapse. As well a reduction in prolapse symptoms and better quality of life at follow-up periods. The study recommended provision of instructional booklets to women with pelvic organ prolapse for improving knowledge, compliance and reducing symptoms.