| publication name | Evaluation of Transforming Growth Factor- β 1 Gene Expression and Polymorphism in Diagnosis of Hepatocellular Carcinoma in HCV-Infected Patients |
|---|---|
| Authors | Fatma M. Abdel Salam a, Maha Z. Omar a, Shuzan A. Mohammed b, Abeer M. El- Bahy a |
| year | 2020 |
| keywords | |
| journal | Benha Journal |
| volume | 33 |
| issue | 1 |
| pages | 1-9 |
| publisher | Not Available |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background: Transforming growth factor-beta1 (TGF-β1), a member of transforming growth factor beta family, functions as a multi-functional cytokine and plays a key role in cellular growth, proliferation and differentiation. Aim of the work: To evaluate the role of TGF-β1 polymorphisms 509 C>T and TGF-β1 Gene expression in diagnosis of hepatocellular carcinoma (HCC) in cirrhotic Egyptian patients due to hepatitis C virus (HCV). Subjects and methods: Thirty five cirrhotic with HCC patients, thirty cirrhotic without HCC patients and 20 healthy volunteers were enrolled in this study. TGF-β1 gene expression in peripheral blood was quantitated using real-time polymerase chain reaction and molecular study of TGF-β1 509 C>T (rs1800469) polymorphism by Taqman allele discrimination was done for all subjects. Results: Showed that TGF-β1 -509 CT genotype was the