Staff Members - Benha University
Mean Platelet Volume and Mean Platelet Volume/Platelet Count Ratio as Diagnostic Markers for Hepatocellular Carcinoma in Chronic Hepatitis C Patients
Afro-Egypt J Infect Endem Dis • 2018
Publication Information
Authors
Maha Z. Omar1, Mohebat H. Gouda2, Mona M. Elbehisy
Keywords
MPV and MPV/PC ratio are
less sensitive and specific than AFP in
diagnosis of HCC. So AFP is still the gold
standard marker in diagnosis of HCC and
MPV and MPV/PC ratio may be used only
in association with other markers like
AFP to improve sensitivity of tumor
detection.
Journal
Afro-Egypt J Infect Endem Dis
Publisher
Not Available
Volume
8
Issue
1
Pages
15-23
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
Background and study aim:
Hepatocellular carcinoma (HCC) is the
most common primary malignant tumor
of the liver. AFP is the gold standard
tumor marker for HCC, mean platelet
volume (MPV) is a parameter obtained
from complete blood count (CBC) by
automated analyzers, shown to be
increased in multiple malignancies and
inflammatory conditions.This prospective
study was designed to evaluate the
diagnostic usefulness of MPV and MPV/
platelet count (PC) ratio in HCC patients
due to chronic hepatitis C (CHC)
infection.
Materials and Methods: One hundred
and twenty subjects enrolled in this study,
they were divided into 4 equal groups: group
I included 30 healthy subjects (control
group), group II included 30 patients with
chronic viral hepatitis without cirrhosis,
group III included 30 cirrhotic patients
without HCC and group IV included 30
cirrhotic patients with HCC.MPV,
MPV/PC ratio & AFP were evaluated in
all groups. Triphasic CT was done for
patients of group IV to confirm the
diagnosis of HCC. Liver biopsy was done
for patients of group II to confirm the
diagnosis of chronic hepatitis C.
Results: MPV showed higher levels in
HCC group compared to control, CHC,
and cirrhotic groups with p value(
Hepatocellular carcinoma (HCC) is the
most common primary malignant tumor
of the liver. AFP is the gold standard
tumor marker for HCC, mean platelet
volume (MPV) is a parameter obtained
from complete blood count (CBC) by
automated analyzers, shown to be
increased in multiple malignancies and
inflammatory conditions.This prospective
study was designed to evaluate the
diagnostic usefulness of MPV and MPV/
platelet count (PC) ratio in HCC patients
due to chronic hepatitis C (CHC)
infection.
Materials and Methods: One hundred
and twenty subjects enrolled in this study,
they were divided into 4 equal groups: group
I included 30 healthy subjects (control
group), group II included 30 patients with
chronic viral hepatitis without cirrhosis,
group III included 30 cirrhotic patients
without HCC and group IV included 30
cirrhotic patients with HCC.MPV,
MPV/PC ratio & AFP were evaluated in
all groups. Triphasic CT was done for
patients of group IV to confirm the
diagnosis of HCC. Liver biopsy was done
for patients of group II to confirm the
diagnosis of chronic hepatitis C.
Results: MPV showed higher levels in
HCC group compared to control, CHC,
and cirrhotic groups with p value(