Cystic echinococcosis (CE) are commonly found in the viscera of affected hosts. There were different methods of treatment of CE. Surgery is one of these methods by using different scolicidal agents for inactivation of protoscoleces, but they have side effects. Natural herbal extract are safe and have many pharmacological uses in different fields. Nigella Sativa is one of these herbal extract. The present study aimed to evaluate efficacy of Nigella sativa either alone or in combination with Albendazole and when they loaded on Chitosan nanoparticles on murine hydatid cyst. Swiss albino mice were used in this study and classified into eight groups. The drug was administrated two months post infection for another two months duration. After sacrifaction the assessment of size and weight of the cysts were done. The results of this study revealed that, there were significant efficacy in all treated groups p