Introduction: To assess the feasibility of single-incision laparoscopic surgery (SILS) in some urological surgeries. Material and Methods: This prospective study was conducted on 40 patients (27 males and 13 females) from January 2010 to June 2011. Six procedures were done, SILS renal cyst decortication (n = 10), SILS varicocelectomy (n = 10), SILS orchiopexy (n = 10), SILS nephrectomy (n = 3), SILS pyelolithtomy (n = 6) and SILS adrenalectomy (n = 1). Results: Postoperative complications included ileus (10%) and fever (10%) in SILS renal cyst ablation. SILS varicocelectomy had postoperative sequalae as persistent varicocele (10%) and hydrocele (10%). SILS orchiopexy was also done with a success rate 100% in this series. SILS pyelolithotomy was successfully done in 5 out of 6 patients and only 1 patient was converted to conventional laparoscopy. In SILS nephrectomy 1 patient out of 3 was converted to conventional laparoscopy. Conclusion: SILS in urology has proven to be safe and feasible in the hands of experienced laparoscopic surgeons, using specially designed ports and instruments in selected patients.