The aim of this study was to evaluate the hemogram and antibody titre after treatment of babesia bigemina infected animal with imidocarb dipropionate and diminazene aceturate. 30 male, native breed cattle (12-14 month age) were used in this study. Ten animals were used as control healthy group (free of babesia infection) and the other 20 animals were used as infected group as proved by using blood film examination. Results showed significant decrease of RBCs count, Hb concentration and PCV values in infected animals before treatment. Total leukocytes, neutrophils, and monocytes counts showed significant increase, while lymphocyte count showed significant decrease. Treatment with either imidocarb dipropionate or diminazene aceturate improved hemogram changes depending on periods from the beginning of treatment. Serum antibody titre was determined by indirect fluorescent antibody test (IFAT). It increased after one week of treatment. The antibody titre was high after 2 weeks of treatment with imidocarb more than after diminazene treatment. The results of this study demonstrate that the possibility of reinfection with babesia bigemina in cattle is lower after imidocarb dipropionate treatment due to the high level of protective antibodies than after treatment with diminazene aceturate.