The present study aimed to investigate the honey (HY) protective role in opposition to cadmium (Cd) induced chromosomal aberrations of bone marrow and sperm abnormalities. Forty five (45) adult male albino mice were caged into six groups. Mice were injected, i.p, 300 mg HY/kg and/or 0.67 mg CdCl2/kg b.w for 96 h, separately and alternated. The alternated trials were continued for consecutive eight days. Results show that mice injected with cadmium had significant increase in the frequency of aberrant chromosomes as fragment, centric fusion, gap, stickiness and aneuploidy and in sperm abnormality. The administration of HY improved the frequency of the chromosomal aberrations and sperm abnormality induced by Cd.