This research was carried out during both 2019 and 2020 seasons to study the influence of the two investigated factors i.e., Lecont pear budded on two rootstocks (Betulaefolia and Communis) and some mineral and bio-fertilizers on some vegetative growth measurements. Results data showed that, Betulaefolia rootstock was better than Communis rootstock in this respect. Also, Concerning the specific effect of the different bio-fertilizers data indicated that, fertilizer with Nitrobein at 5 g/ transplant + Phosphorein at 5 g/ transplant + Potasein at 5 g/ transplant + Effective microorganisms (EM) at 50 cm./ transplant +3/4 dose of mineral fertilizers (75%) was superior in this respect. Concerning the interaction effect the highest vegetative growth were obtained with the combination between Lecont pear transplants budded on Betulaefolia rootstock and fertilized with soil application of Nitrobein at 5 g/ transplant + Phosphorein at 5 g/ transplant + Potasein at 5 g/ transplant + Effective microorganisms (EM) at 50 cm./ transplant +3/4 dose of mineral fertilizers (75%), however the lowest values were noticed by Lecont pear transplants budded on Communis rootstock and fertilizer with mineral element (control) during the two seasons of study.