This investigation was carried out during both 2015 and 2016 seasons to study the influence of the two investigated factors i.e., pomegranate cultivars (Manfalouty and Wonderful) and fertilization (mineral & bio- fertilization) and their possible combinations on some vegetative growth measurements. The specific effect of cultivar type on some vegetative growth, data revealed that, Wonderful cultivar was better than the other investigated cultivar (Manfalouty cultivar) in this respect. Also, fertilizer with soil application of Nitrobene + Phosphorene + Potasene at 4 g/ transplant for each + 1/4 mineral fertilizers was superior in this respect where it was able to increase significantly vegetative growth as compared with the other different investigated fertilization especially NPK only (control) during both seasons of study. Concerning the interaction effect of the two investigated factors i.e., pomegranate cultivars (Manfalouty and Wonderful) and fertilization (mineral & bio- fertilization) on vegetative growth of pomegranate transplants, data show the highest vegetative growth were obtained with the combination between Wonderful cultivar transplants and fertilized with soil application of Nitrobene + Phosphorene + Potasene at 4 g/ transplant for each + 1/4 mineral fertilizers.