This study was designed to evaluate the relationship between serum lipid concentrations and hearing levels and the impact of dyslipidemia treatment on both variables in apparently healthy subjects. The study comprised 106 subjects (65 males and 41 females) aged 40-49 years. Baseline audiometric evaluation was performed and after fasting >12 hours, blood samples were collected for determination of serum total cholesterol (TC), high density lipoproteins (HDL) and triglycerides (TG). For each variable, subjects were divided into: high-level group (>mean+SD) and low-level group (<mean-SD). Subjects categorized within TC and TG high-level group and those within HDL low-level group were treated with ciprofibrate (100 mg/day for 4 weeks) and then serum lipids estimation and audiometric evaluation were repeated. There was a significant (P<0.05) decrease of serum TC in females categorized as both high- and low-level groups and a significant (P<0.05) increase of serum HDL in females included in high-level group compared to male levels. Audiometric studies showed significantly (P<0.05) impaired hearing level, at 2000 and 4000 Hz in males with TC high-level compared to those with low-level and in both males and females with low HDL compared to those with high HDL. There was a positive significant correlation between hearing level and serum HDL in females and males (r=0.638 & 0.512, PO.001, respectively) and a negative significant correlation v/ith TC in both females and males (r=-0.565 & -0.452, P<0.001, respectively). Treatment with ciprofibrate significantly decreased serum levels of TC and TG and increased serum HDL in comparison to the pretreatment levels in both sexes, and resulted in significant (P<0.05) improvement of hearing level (post-treatment) compared to pre¬treatment levels at 2000 and 4000 Hz in both gender, despite the significant (PO.05) difference in favor of females. We can conclude that dyslipidemia in the form of increased TC and decreased HDL in particular in men is associated with decreased hearing level especially at 2000 and 4000 Hz, and that lipid-lowering therapy is beneficial for improving the auditory functions of affected subjects. Zagazig Medical Journal : تاريخ النشر 2001