Staff Members - Benha University
Association of HLA Class I and II Antigens with Vitiligo in Egyptian Population
Molecular Enzymology and Drug Targets • 2016
Publication Information
Authors
Ayman Elgendy; Eslam Alshawadfy; Eman Ali;Nancy Wadea; Karem Khalil; Osama Alkady; Ahmed Elsaidi
Keywords
HLA Class I and II antigens; Vitiligo; Egypt
Journal
Molecular Enzymology and Drug Targets
Publisher
Not Available
Volume
2
Issue
1
Pages
1-6
publication.type
International
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
The association of HLA antigens with vitiligo remains controversial issue.In order to determine which, if any,HLA markers were associated with an increased risk of vitiligo, we investigated HLA antigens in 50 patients with vitiligo and in 50 controls. vitiligo patients had significant increase in HLA-A1, A19, B16, CW4, CW 6, DR 4, DR7 and DQ3 compared to controls. Familial vitiligo is marked by increased frequency of HLA-A28, B16, B27, B48, CW2 and DQ3, while non-familial vitiligo is marked by increased frequency of HLA-A1, CW6 and DR13. These findings suggest that immunogenetic mechanism may be responsible for vitiligo. Also there may be heterogeneity in the pathogenic process between familial and non familial vitiligo.