Bisphenol- A (BPA), an estrogenic compound, is used in manufacture of polycarbonate plastics and epoxy resins. Sesame oil is a potent antioxidant dietary source for human health. Aim of the work: The present study is conducted to estimate the protective effects of sesame oil (SO) against bisphenol-A (BPA) induced Cardiotoxicity. Material and methods: Thirty two adult rats were divided into 4 equal groups eight rat for each; Control group, 2 Treated group, one group received BPA ( 25 mg/kg b wt) orally 5 times/weak for 4 weeks and other group rats received (50 mg/kg b. wt) orally 5 times /weak for 4 weeks. Protected group received sesame oil orally at a dose 10mL/kg b wt orally daily for 4 weeks to the rat group which received the high dose of BPA. After the end of treatments, the heart of each sacrificed animal was subjected to histopathological examination by H&E, masson's and INos stain. In addition, blood was collected for biochemical assessment of the enzymes. Results: Administration of high dose BPA (50mg/kg b wt) significantly increased the weight of rats, several histopathological alterations in cardiac tissue and elevation in MDA , CK-MB and GST and reduction of GSH and catalase when compared to the control. Low dose BPA (25mg/kg b wt ) produced mild histoapatholgical effect on the heart , On the contrary, oral gavages of sesame oil with BPA was effective in the reduction of weight, amelioration of histopathological alterations, and in the reduction of the MDA , CK-MB and GST levels and elevation of GSH and catalase activity when compared to high dose BPA's treated rats. Conclusion: The present study provided clear evidence that sesame oil possesses a promising protective activity against the cardiotoxic effects of bisphenol