Two types of nanosized oxides (Fe2O3 and TiO2) were prepared by simple and ecofriendly method. The as-prepared nano oxides were characterized by Thermogravimetric analysis, FTIR, XRD and HRTEM. As applications, the nano Fe2O3 was tested as photo catalyst for the decontamination of methylene blue (MB) as organic pollutant and the efficiency of TiO2 for the removal of Zn (II) and Pb (II) from water sample were extensively studied. The different factors (time, pH, initial concentration of pollutants and dose of sorbent), sorption mechanism and kinetics of the removal process were studied. The antimicrobial activities of the nano oxides were tested against two of Gram – positive bacteria (Streptococcus pyogenes and Staphylococcus epidermidis) and two Gram – negative bacteria (Proteus vulgaris and Klebsiella pneumonia). Standard drug; levofloxacin and DMF solvent control were screened separately for their antibacterial activity. The antibacterial results showed that the as prepared nanooxides exhibit high activity against the tested organisms. The activity is in the order TiO2 > Fe2O3