Staff Members - Benha University
Nephrotoxicity of Tow Food Additives (Aspartame and Monosodium Glutamate) in Adult Albino Rats: Biochemical and Histopathological Effects
IOSR Journal of Environmental Science, Toxicology and Food Technology • 2019
Publication Information
Authors
Abdelmonem G Madboly M; Eslam S Metwally; Ghada A Abd
El-Fattah
Keywords
Nephrotoxicity, Food Additives, Aspartame, Monosodium Glutamate, Recovery
Journal
IOSR Journal of Environmental Science, Toxicology and Food Technology
Publisher
International Organization of Scientific Research
Volume
13
Issue
4
Pages
20-29
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
Both aspartame (ASP) and monosodium glutamate (MSG) are added to many food stuffs, hence any
meal may contain both of them, so their harmful effects should be studied together. Evidences of ASP
nephrotoxic effect have increased; however, little information is available about nephrotoxicity of MSG. This
study assessed the nephrotoxic effects of ASP & MSG administered either individually or in-combination. Forty
eight male adult albino rats were divided into eight equal groups: negative control; positive control; ASPtreated;
MSG-treated; “ASP&MSG”-treated; ASP-recovery; MSG-recovery and “ASP&MSG”-recovery. A
single daily dose of ASP (250mg/kg) and MSG (4g/kg) were given orally according to the study regimen. The
present study documented nephrotoxic effects of ASP and MSG evidenced by a significant increase in serum
urea, creatinine and tissue malondialdehyde levels; a significant decrease in tissue reduced glutathione level;
and renal structural damages detected in all treated groups. The worst findings were detected in “ASP+MSG”-
treated group. Partial improvement in the renal histopathological and biochemical results was detected in all
recovery groups.
meal may contain both of them, so their harmful effects should be studied together. Evidences of ASP
nephrotoxic effect have increased; however, little information is available about nephrotoxicity of MSG. This
study assessed the nephrotoxic effects of ASP & MSG administered either individually or in-combination. Forty
eight male adult albino rats were divided into eight equal groups: negative control; positive control; ASPtreated;
MSG-treated; “ASP&MSG”-treated; ASP-recovery; MSG-recovery and “ASP&MSG”-recovery. A
single daily dose of ASP (250mg/kg) and MSG (4g/kg) were given orally according to the study regimen. The
present study documented nephrotoxic effects of ASP and MSG evidenced by a significant increase in serum
urea, creatinine and tissue malondialdehyde levels; a significant decrease in tissue reduced glutathione level;
and renal structural damages detected in all treated groups. The worst findings were detected in “ASP+MSG”-
treated group. Partial improvement in the renal histopathological and biochemical results was detected in all
recovery groups.