| publication name | Reliability of Fibronectin and P-selectin as Indicators of Vitality and Age of Wounds: An Immunohistochemical Study on Human Skin Wounds |
|---|---|
| Authors | Eslam S. Metwally, Abdelmonem G. Madboly, Amina A. Farag,Taghreed Abdel Samea, and Hesham A. Farag |
| year | 2018 |
| keywords | Fibronectin, P-selectin, Immunohistochemical, Wound vitality, Scoring system, Wound age. |
| journal | Mansoura J. Forensic Med. Clin. Toxicol. |
| volume | 26 |
| issue | 2 |
| pages | 83-99 |
| publisher | Department of Forensic Medicine and Clinical Toxicology Mansoura Faculty of Medicine |
| Local/International | Local |
| Paper Link | Not Available |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Fibronectin and P-selectin are immunohistochemical markers of skin wounds vitality and age estimation. This study aimed to assess and compare between fibronectin and P-selectin as markers of vitality and dating of antemortem (AM) and postmortem (PM) human skin wounds. This study was carried out on 140 human cases that were classified into 3 main groups; Group I [90 cases received at the Emergency Department, Benha University Hospital, Egypt, were sub-classified according to the wound age: AM1 (12 hours; n =20) and Group III [10 normal control skin samples]. Immunohistochemical (IHC) staining technique was performed for all full thickness skin biopsies. The current study confirmed that P-selectin & fibronectin were good markers of wound vitality & designed a scoring system based on the increased intensity of the IHC staining in relation to wound age. The current study concluded that P-selectin is more reliable and specific than fibronectin as a marker of wound age estimation & vitality.