Staff Members - Benha University
Prevalence of silent hepatitis B and HCV genotype among chronic hepatitis C patients
• 2007
Publication Information
Authors
Ebrahim M. Rageh,MD.: Mahasen Abdel Sattar,MD.: Adel f.Al-Kholy,MD.: Hossam Amin MD
Keywords
Not Available
Journal
Not Available
Publisher
Not Available
Volume
Not Available
Issue
Not Available
Pages
Not Available
publication.type
Local
Paper Link
Not Available
Supplementary Materials
Not Available
Abstract
This multi-center study was designed as a trial to explore ,h:: pn! Jknce of silent hepatitis B infection among hepatitis C FJ:i.:r.t" Jnd to determine the prevalent genotype of hepatitis C !rllS ,HC\'I in these patients. The study comprised 45
\ ith posr-hepatitic liver cirrhosis. All patients gave '=':0L,j samples for estimation of liver function tests, ELISA '::slIm:Jtion of serum levels of hepatitis B surface antigen . HBsAg I. anti·Hey antibodies and Hey core antigen. patients ., ith HB,.-g positi·e were excluded off the study. Qualitative de:e..:tlon of HeV RN A and HB V ON A by peR (home-made peRi and Quantitative PCR for estimation of HCY viremia :md Hey genotyping: by REFLP technique were performed. Th.: HCY-Ab was detected in all and HCY-Ag in 42 samples
9;.3'1 ) irrespective of its clinical severity class with a mean yire!11ia leeJ of 792336.7±400074.8; range: 134985-1957632 .. iral copy/mJ as determined by quantitati ve PCR. There was .1 non-significant difference between severity clinical classes as regards the qualitative or quantitative detection of HCV infection. The HBY DNA was detected using qualitative PCR in 20 samples (44.4%); 4 class A, 7 class Band 9 class C samples with a significant increase of the frequency of silent HB in patients with class B (X2=5.446, p
\ ith posr-hepatitic liver cirrhosis. All patients gave '=':0L,j samples for estimation of liver function tests, ELISA '::slIm:Jtion of serum levels of hepatitis B surface antigen . HBsAg I. anti·Hey antibodies and Hey core antigen. patients ., ith HB,.-g positi·e were excluded off the study. Qualitative de:e..:tlon of HeV RN A and HB V ON A by peR (home-made peRi and Quantitative PCR for estimation of HCY viremia :md Hey genotyping: by REFLP technique were performed. Th.: HCY-Ab was detected in all and HCY-Ag in 42 samples
9;.3'1 ) irrespective of its clinical severity class with a mean yire!11ia leeJ of 792336.7±400074.8; range: 134985-1957632 .. iral copy/mJ as determined by quantitati ve PCR. There was .1 non-significant difference between severity clinical classes as regards the qualitative or quantitative detection of HCV infection. The HBY DNA was detected using qualitative PCR in 20 samples (44.4%); 4 class A, 7 class Band 9 class C samples with a significant increase of the frequency of silent HB in patients with class B (X2=5.446, p