Abstract: Background: Children burns are immediately and potentially life-threatening injuries. A child with the burn is being at high risk due to the rapidly changing physiologic status, and the multiple complications. The aim of the study: the aim of the current study has three folds to compare the nurse’s performance with burn- injured children at pediatric burn unit before/after the program. Assessing barriers facing nurses in pediatric burn care unit from a holistic view. To identify the relationships between selected nurse's demographic characteristics and their level of knowledge and performance. Design: A quasi-experimental design was used in the current study. Sitting: the study carried out in the pediatric burn unit at the Teaching Hospitals in Benha City. Sample: A convenient sample of all nurses (55) in the pediatric burn unit were enrolled in this study. Tools: Three tools were used to collect data which included: Tool I: Interviewing questioner sheet categorized into two part: 1-Demographic characteristics as age, level of education and years of experience 2- Nurses' knowledge assessment sheet (Women's and children hospital (2010). Tool II: An observational checklist adopted from American Burn Association (2015) to assess nurses’ performance in pediatric burn unit before/after the program. Tool III: The barriers facing nurses in pediatric burn care unit was adopted from (Nyakanda, 2012) composed of 9 items. Likert scale collapsed into three categories always, sometimes and never. Results: The study results revealed that after the implementation of the program, 93% of nurses had a satisfactory level of knowledge about burn in the pediatric patient. As well as 94% of nurse had a satisfactory level of performance. There was a statistically significant difference between nurse’s level of knowledge and performance before and after the implementation of the program. Conclusion: The education program about burn care was effective and improving nursing performance at the pediatric burn unit. Recommendation: The study recommended that nurses worked at the pediatric burn unit were needed continuous updates in their knowledge and performance regarding burn care of children.