Background: Nocturnal enuresis can affect negatively on the familial quality of life. Therefore, parents and their children should be educated about intervention to overcome these disorders. The aim: Evaluate the effect of educational module on school age children and their parent’s knowledge, and behavior intervention about nocturnal enuresis. Design: The study utilized a quasi-experimental research design. Setting: Outpatient clinic affiliated to the Specialized Pediatric Hospital at Benha City. Sample: A purposive sampling technique was used consisted of sixty school age children diagnosed by nocturnal enuresis and their parent. The tool of data collection: Tool I: A structured interviewing questionnaire about characteristics of children and their parents, the pattern of enuresis and knowledge of school-age children and their parent about nocturnal enuresis.Tool II: Behaviour intervention. Results: 51.7% of the school-age children with enuresis were female and 53.3% of them were living in urban, 46.7% were taken last drink before sleep. 81.7% of schoolage children have had no family history of nocturnal enuresis. 56.70% of children and 75% of parent have satisfactory knowledge post program implementation. Also, 65.0% of children and 67.0% of parent have appropriate behavior about nocturnal enuresis post program implementation. Conclusion: The educational module program was influenced positively in improving school-age children and their parent’s knowledge and behavior intervention about nocturnal enuresis. Recommendations: Updates and continuous counseling program for parent and their children with nocturnal enuresis are critical to improve their knowledge, early detect and intervention to avoid the negative consequences of nocturnal enuresis.