| publication name | Changes in cardiac function during the development of uremic cardiomyopathy and the effect of Salvianolic acid B administration in a rat model |
|---|---|
| Authors | Danfu Ma, Ahmed S Mandour, Ahmed Elfadadny, Hanan Hendawy, Tomohiko Yoshida, Hussein M El-Husseiny, Koji Nishifuji, Ken Takahashi, Yanbin Zhao, Zhenlei Zhou, Ryou Tanaka |
| year | 2022 |
| keywords | |
| journal | Frontiers Veterinary Science - Veterinary Imaging |
| volume | 9:905759. |
| issue | Not Available |
| pages | 734 |
| publisher | Not Available |
| Local/International | International |
| Paper Link | https://doi.org/10.3389/fvets.2022.905759 |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
Background Uremic cardiomyopathy (UC), the main cause of death in progressive chronic kidney disease (CKD), is characterized by diastolic dysfunction. Intraventricular pressure gradients (IVPG) derived from color m-Mode echocardiography (CMME) and two-dimensional speckle tracking echocardiography (2DSTE) were established as novel echocardiographic approaches for non-invasive and repeatable assessment of cardiac function. Previously, salvianolic acid B (Sal B) showed the potential to alleviate concentric LV hypertrophy in the pressure overload model. The purpose of this study was to evaluate the changes in cardiac function in UC and assess the efficacy of Sal B therapy using IVPG and 2DSTE techniques. Materials and methods Twenty-four rats underwent subtotal nephrectomy to produce progressive renal failure and were allocated equally into UC(n=12) and Sal B-UC(n=12) groups and …