The present study was conducted to evaluate the analgesic potential of the new triamilidemacrolide antibiotic, tulathromycin, at 20 and 40 mg/kg of body weight (BW), subcutaneouslyagainst acute pain in mice. Acute pain was induced either chemically (using acetic acid-inducedwrithing and formalin-induced pain tests) or thermally (using hot-plate, and tail-flick tests). In theacetic acid-induced writhing test, tulathromycin induced a dose-dependent and significant decreasein the number of writhes compared with the control group. In the late phase of the formalin test, asignificant decline in hind paw licking time compared with the control group was observed. In thehot-plate and tail-flick tests, tulathromycin caused a dose-dependent and significant prolongation oflatency of nociceptive response to heat stimuli, compared with the control group. These findingsmay indicate that tulathromycin possesses significant peripheral and central analgesic potentials thatmay be valuable in symptomatic relief of pain, in addition to its well-established antibacterial effect.

(PDF) pharmaceutics The Anti-Nociceptive Potential of Tulathromycin against Chemically and Thermally Induced Pain in Mice. Available from: https://www.researchgate.net/publication/353842039_pharmaceutics_The_Anti-Nociceptive_Potential_of_Tulathromycin_against_Chemically_and_Thermally_Induced_Pain_in_Mice [accessed Aug 12 2021].