Objective To evaluate the safety and efficacy of platelet rich plasma (PRP) injections as a therapeutic modality for mild to moderate erectile dysfunction. Method A placebo controlled study of 100 cases with mild to moderate erectile dysfunction. Participants were allocated to 2 groups; the PRP group received 3 injections (3ml each corpus) and the interval between injections was 15 days, while the Placebo (Saline) group received 6ml saline injected intracavernous. Post injection follow up lasted 6 months. Results Compared to the placebo group, the PRP group demonstrated a significant improvement at the 1 and 3 months follow up that slightly dropped at the 6 months follow up (p