This study was done to investigate the ameliorative effect of Parsley extract and one-alpha on KBrO3 induced
nephrotoxicity in rats. Fifty rats were classified into 5 groups: Group 1 :( normal control group): rats
injected once with normal saline I/P. Group 2: (nephrotoxic group) rats injected with single dose of KBrO3
(130 mg/kg B.wt, I/P). Group 3:(parsley treated group) rats received KBrO3 then after 3 days treated with
parsley extract at a dose of (400 mg/kg.b.wt /day/6 weeks ) orally. Group 4 (one alpha treated group) Rats
injected once with KBrO3 at a dose of ( 130 mg/kg B.wt, I/P) and after 3 days treated with one-alpha at a
dose of (0. 2μg /day / 6 weeks.) orally. Group 5: (parsley extract + one alpha treated group) Rats injected
once with by KBrO3 at a dose of ( 130 mg/kg B.wt, I/P) and after 3 days treated with both of parsley extract
(400mg/kg b.wt/day/6 weeks) and one – alpha (0.2μg/ day / 6 weeks) orally. Nephrotoxic group showed a
significant increase in serum creatinine activity urea and uric acid concentration when compared with
normal control in addition to significant increase of renal tissue NOs, TNF- α, L-AGAT and caspase-3
concentration, on the other hand, serum 1-α hydroxlase activity showed significant decrease of nephrotoxic
group in comparison to normal control. Treatment with parsley or one alpha or both revealed return of these
parameters to nearly normal level. Parsley or one alpha may thus be used as a potentially promising agent to
inhibit nephrotoxicity and may be a novel natural products for management of nephrotoxicity.