Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. This study was conducted to evaluate the neurooprotective effect of aluminium chloride induced neuroyoxicity in rats. Fourty rats used in this study were divided into two groups: control group, rats were received normal laboratory diet all over the period of the experiment for 8 weeks, aluminum chloride protective group received (i.p) injection of AlCl3 daily at dose (300mg/kg).. The results revealed that injection of AlCl3 affected on oxidative stress markers. Where, levels of malondialdehyde (MDA), myeloperoxidase (MPO), total antioxidant capacity (TAC) and nitric oxide (NO) were significantly increased and AlCl3 also reduced superoxidase dismutase (SOD), glutathione peroxidase (Gpxas), catalase (CAT) and glutathione (GSH). It can be concluded that AlCl3 caused brain oxidative damage