Neurotoxicity is a form of toxicity in which a biological, chemical, or physical agent produces an adverse effect on the structure or function of the central and/or peripheral nervous system. This study was conducted to evaluate the neurotoxic effect of aluminium chloride induced neuroyoxicity in rats. Fourty rats used in this study were divided into two groups: control group, rats were received normal laboratory diet all over the period of the experiment for 8 weeks and aluminium chloride protective group received (i.p) injection of AlCl3 daily at dose (300mg/kg). The results revealed that injection of AlCl3 effected on inflamatory markers where, levels of interleukin (il-2), interleukin-6 (il-6) Tumer Necrosis Factor (TNF α) were significantly increased