Obesity is the most prevalent nutritional disorder. Healthy diets helps people maintain and improve their general health. This study aimed to assessment of low and very low calorie diets through determination of its effect on lipid metabolism, iron profile and kidney function in obese male rats. To achieve our aim forty five male albino rats were used and divided into 4 groups: control group, obese group with 75 calories diet, obese group with 60 calories diet and obese group with 45 calories diet. Our result showed significant disturbance of lipid, iron and kidney profile on supplementation of 75 calories diet to obese group of male rats and significant improvement in lipid, iron and kidney profile on supplementation of 60 calories diet or 45 calories diet to obese group of male rats. The results confirmed that, high fat diet able to produce significant disturbance in lipid metabolism, iron profile and kidney function while low calorie diets able to improving the disturbance in such parameter.