Gastroenteritis is a major health problem, especially in developing countries including Egypt. Chamomile has been used in the traditional
medicine for the management of gastrointestinal disorders. The aim of this study was to evaluate biochemical alterations of inflammatory biomarkers
in gastroenteritis after administration of chamomile oil. In order to achieve this aim 30 male albino rats was divided into two main groups, healthy
control group and induced gastroenteritis group by using enteropathogenic E. coli. Half of them kept as positive control and the remaining treated
with chamomile oil. The results of the present study showed a significant association between exposure to bacterial gastroenteritis and high level
of inflammatory biomarkers like IL2, IL6, TNF, histamine and cortisol. The results also showed a significant decrease in inflammatory biomarkers
IL2, IL6, TNF, histamine and cortisol in gastroenteritis group upon administration of chamomile oil. These findings suggested that chamomile oil
possess anti-inflammatory activity confirming their traditional use.