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Comparative Effects of Purslane seed oil (PSO) and 5- Flourourasil on Ehrlich ascites carcinoma (EAC) in female albino mice
International Journal of Pharma Sciences Vol. 4, No. 1 (2014): 424-430 • 2016
Publication Information
Authors
Hussein A. Ali1, Mohammed A. Hussein2,*, Walaa E. Mohammed1
Keywords
Keywords: Purslane seed oil (PSO), 5-Flourourasil, breast cancer, Ehrlich ascites cells and antioxidants
Journal
International Journal of Pharma Sciences Vol. 4, No. 1 (2014): 424-430
Publisher
aizeon publisher
Volume
Vol. 4, No. 1 (2014): 424-430
Issue
Vol. 4, No. 1 (2014): 424-430
Pages
Vol. 4, No. 1 (2014): 424-430
publication.type
International
Paper Link
Open Link
Supplementary Materials
Not Available
Abstract
ABSTRACT
The present study was to evaluate anti-cancer effects of Purslane seed oil (PSO) (200g/kg. diet), 5-Flourourasil
(20mg/kg b.w. i.p) and their combinatorial formulation in female mice induced by Ehrlich ascites cells for 21
consecutive days prior. Ten days after intraperitoneal inoculation of tumor EAC cells in mice, PSO was supplemented
at (200g/kg. diet) daily for 21 consecutive days. On the 22th day, the mice were sacrificed for the estimation of tumor
growth (tumor volume), and biochemical parameters (glucose, insulin, alanine transaminase (ALT), aspartate
transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxides (TBARS), protein
thiols (Pr-SHs), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), total
cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, 17β-estradiol and progesterone). The results of this study also
showed that administration of Purslane seed oil (PSO), 5-Flourourasil both individually and in combination for 21
days to the carcinoma induced mice demonstrated a significant (P
The present study was to evaluate anti-cancer effects of Purslane seed oil (PSO) (200g/kg. diet), 5-Flourourasil
(20mg/kg b.w. i.p) and their combinatorial formulation in female mice induced by Ehrlich ascites cells for 21
consecutive days prior. Ten days after intraperitoneal inoculation of tumor EAC cells in mice, PSO was supplemented
at (200g/kg. diet) daily for 21 consecutive days. On the 22th day, the mice were sacrificed for the estimation of tumor
growth (tumor volume), and biochemical parameters (glucose, insulin, alanine transaminase (ALT), aspartate
transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxides (TBARS), protein
thiols (Pr-SHs), reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), total
cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, 17β-estradiol and progesterone). The results of this study also
showed that administration of Purslane seed oil (PSO), 5-Flourourasil both individually and in combination for 21
days to the carcinoma induced mice demonstrated a significant (P