The present study aimed to trigger the effect of experimentally induced chronic hepatic failure on tissues antioxidant status in different ages the hepatic failure induced by Intraperitoneal administration of Thioacetamide at a dose of (30 - mg/kg body weight) four times through two months with 15 days interval Rats were sacrificed 24 hrs after the last dose of TAA the recorded data revealed significant decrease in Brain tissue Monoaminooxidase (MAO) and significant increase in brain tissue nitric oxide (NO) and ammonia, significant decrease in Brain, kidney, muscles and hepatic tissues Reduced Glutathione (GSH) Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPX) from the recorded results it could be concluded that hepatic failure is a hazard stress in tissues antioxidants in different ages