The present study was aimed to evaluate the protective effective role of cranberry extract against ironoverload
induced hepatic toxicity in rats. By administration of iron sulfate (30 mg/kg body weight)
orally for 21 days, led to significantly increases in the levels of hemoglobin, glucose, lipid profile,
plasma and hepatic lipid peroxidation, iron and transferrin. Also, the oral administration of iron sulfate
showed a significant decrease in the levels of plasma and liver enzymatic and non-enzymatic
antioxidants. Administration of cranberry extract at different doses (75 and 150 mg/kg body weight)
significantly restore the levels of plasma and hepatic markers, lipid profile, lipid peroxidation as well as
increased the levels of plasma and hepatic antioxidants with normal plasma iron and transferrin
concentration in blood. Cranberry extract at a dose of 150 mg/kg body weight exhibits significant
protection on hepatic antioxidants more pronounced than both cranberry 75 mg/kg.b.w. and vitamin C.
On the other hand, the results clearly suggest that the cranberry extract may be effective in enhances the
protection of liver toxicity by its free radical scavenging effect and antioxidant activity.