| publication name | Antioxidant and Lung Protective Effects of Moringa peregrina seeds oil against benzene and/or Fluorouracil induced leukopenia in Rats |
|---|---|
| Authors | Abdel-Maksoud HA1, Mohammed A. Hussein2, Afaf D. Abd El Mageed3 and Wafaa Abd El Zaher Taha4 |
| year | 2015 |
| keywords | Moringa peregrina seeds oil, 5-Fluorouracil, benzene, leukopenia and antioxidants. |
| journal | Intternattiionall Journall of Pharma Sciiences |
| volume | Vol. 5 |
| issue | No. 4 (2015) |
| pages | 1108-1116 |
| publisher | aizeon publisher |
| Local/International | International |
| Paper Link | http://ijps.aizeonpublishers.net/15vol5-4.html |
| Full paper | download |
| Supplementary materials | Not Available |
Abstract
ABSTRACT The present study was to evaluate anti-leukopenia and antioxidant effects of Moringa peregrina seeds oil at 381mg/kg.in 400mg/kg.b.w. benzene and/or 20mg/kg.b.w.,5-Fluorouracil induced leukopenia rats. 2 weeks after induction of leukopenia in rats, Moringa peregrina seeds oil at 381mg/kg. was administrated for 30 consecutive days. On the 31th day, the rats were sacrificed for the estimation of hemoglobin (Hb%), complete blood cell count Leucocyte (WBC) and platelet count (PLT), as well as biochemical parameters; alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxides (TBARS), reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), total cholesterol (TC), triglycerides (TG), HDL-C, LDL-C, p53gene expression, nitric oxide (NO) and tumor necroses factor-α (TNF-α). The results of this study also showed that administration of Moringa peregrina seeds oil at 381mg/kg.b.w. to leukopenia induced rats demonstrated a significant (P