ABSTRACT Nanoparticles have one dimension that measures 100 nanometers or less. The properties of many conventional materials will be changed when they are in nanoparticle form. This is typically because nanoparticles have a greater surface area per weight than larger particles which make them to be more reactive to other molecules. The aim of this study to demonstrate the biochemical effect of basic curcumin – zinc oxide nanocomposite modified with vitamin C and surfactant induced experimentally in female mice. This study was carried out on 80 mice and weighted 25-30 gm. Blood samples were collected from all animals groups after 2, 4 and 6 weeks of treatment. Serum were separated and processed directly for (AST and ALT) activities, (Urea, Creatinine, Nitric oxide) concentration and Interleukin-6 (IL-6) and Interleukin-8 (IL-8) levels. The obtained results revealed that, these the novel nanocomposite have a very important role in improving liver & kidney functions and pro inflammatory agents.