Background: In terms of health, chronic obstructive pulmonary disease (COPD) is a major problem. It is a major global cause of illness and mortality. It is anticipated that by 2030, it will rank third globally in terms of both mortality and disability. Aim: The study aimed to evaluate the effect of Orem's self-care behavior on the quality of life of elderly patients with chronic obstructive pulmonary disease in Benha City. Methods: This study used a quasi- experimental (pre/post-test) design. 100 elderly patients with chronic obstructive pulmonary disease comprised the purposive sample for the study, which was done at the outpatient clinics of the chest hospital in Benha City, Egypt. The data were gathered using a self-administered questionnaire, an observational checklist for older people practicing COPD, the Quality-of-Life Scale (QOLS), and the COPD Self-Care Behavior Scale (COPDSC). Results: After the model was implemented, there were improvements in self-care behavior for 55% of the elderly patients who had been studied, satisfactory practices for 81%, and good total quality of life scores for 72% of them (p