Staff Members - Benha University
GENE PROMOTER 469 E/K POLYMORPHISM OF THE INTERCELLULAR ADHESION MOLECULE-1 GENE ASSOCIATION WITH AMI IN TYPE 2 DIABETIC PATIENTS
• 2012
Publication Information
Authors
Seham A Khodeer (MD), Azza M. Abdu-Allah (MD), Mohamed Al-Assal (MD), and Hesham K Rashid (MD).
Keywords
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Journal
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Publisher
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Volume
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Issue
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Pages
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publication.type
International
Paper Link
Open Link
Supplementary Materials
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Abstract
Background: ICAM-1 has a vital responsibility in the adhesion of circulating leucocytes to the blood vessel wall and subsequent transendothelial migration to the vascular intima, one of the earliest stepladders in atherogenesis.
Objective: To investigate the possible role of the K469E polymorphism of the ICAM-1 in genetic susceptibility to MI amongst the patients with type 2 diabetes.
Subjects &Methods: The study included 70 patients divided into two groups: Group I included 35 patients suffering from type 2 DM with MI, Group II included 35 patients with type 2 DM without CAD, 30 apparently healthy age and gender matched subjects were involved as a control group. For all subjects the followings were done: History taking & clinical examination, ECG, lipid profile, HbA1c, sICAM-1 by ELISA. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method was used to determine the distribution of allele and genotype frequencies of the 469 E/K polymorphism of the ICAM-1.
Results: There were high statistical significant between ICAM level of Group 1 (468±40.4 ng/ml) and both Group II (266.4±44.1 ng/ml) & the controls (150.6±29.7ng/ml p
Objective: To investigate the possible role of the K469E polymorphism of the ICAM-1 in genetic susceptibility to MI amongst the patients with type 2 diabetes.
Subjects &Methods: The study included 70 patients divided into two groups: Group I included 35 patients suffering from type 2 DM with MI, Group II included 35 patients with type 2 DM without CAD, 30 apparently healthy age and gender matched subjects were involved as a control group. For all subjects the followings were done: History taking & clinical examination, ECG, lipid profile, HbA1c, sICAM-1 by ELISA. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method was used to determine the distribution of allele and genotype frequencies of the 469 E/K polymorphism of the ICAM-1.
Results: There were high statistical significant between ICAM level of Group 1 (468±40.4 ng/ml) and both Group II (266.4±44.1 ng/ml) & the controls (150.6±29.7ng/ml p