Hepatitis C is a major health problem. Chronic hepatitis C is a slowly progressive inflammatory disease which can lead to cirrhosis with all its complications [lJ. In Egypt, the prevalence rate reaches 15% in rural areas, with some age groups suffering from prevalence rates up to 50%. 13.6% of volunteer blood donors have anti-HCV antibodies, this high seropositive rate among Egyptians is about 35 folds higher than other . countries [21. Liver fibrosis is the excessive accumulation of extracellular matrix proteins including collagen that results from chron ic damage to the liver [3]. The assessment of the stage of liver fibrosis is esseptial for prognosis and for deciding on antiviral treatment [4].