The aim of this study was to evaluate the effect of nursing intervention on pelvic organ prolapse symptoms. Design: A quasi experimental design was utilized. Setting: The study was conducted at Gynecological Outpatient Clinic affiliated to Benha University Hospital. Sample: A purposive sample of 45 women recruited in the study according to inclusion criteria. Tools: Four tools were used for data collection; 1) a structured interviewing questionnaire which comprised of four main parts: general characteristics of the studied women, obstetric and gynecological history, women knowledge about pelvic organ prolapse, and women' perceived change in prolapse symptoms. 2) Women' compliance toward recommended nursing instructions sheet, 3) pelvic organ prolapse symptoms scale and 4) pelvic organ prolapse impact questionnaire. Results: There was a significant improvement in women' knowledge regarding pelvic organ prolapse and compliance toward recommended nursing instructions (p˂0.000). Additionally, mean scores of pelvic organ prolapse symptoms and quality of life measured by pelvic organ prolapse impact questionnaire were remarkably reduced after one month and three months compared to before nursing intervention (p˂0.000). Conclusion and recommendation: Nursing intervention was effective in reducing prolapse symptoms and improving quality of life. The study recommended that provision of nursing instructional booklets to women with pelvic organ prolapse for improving knowledge, compliance and reducing symptoms.