Uterine prolapse is the most frequently reported cause of poor health among women of reproductive age and postmenopausal. It is known to cause physical and psychosocial problems affecting the quality of women life. The current study aimed to evaluate the effect of the evidence-based nursing intervention on relieving uterine prolapse symptoms and degree. Design: An intervention research design (time series) was adopted. A purposive sampling technique was used to recruit 40 women at gynaecological outpatient and family planning clinics in El- Nabawy El Mohandes Hospital, Fayoum. Four tools of data collection were used: Structured interviewing questionnaire, Pelvic organ Prolapse Quantification system, uterine prolapse associated symptoms follow up sheet and self-reported changing in symptoms and degree post-intervention tool. Results: revealed that there was a statistically significant improvement in women’s knowledge regarding the uterine prolapse and its management. Also there was a highly statistical significant difference between mean score of uterine prolapse symptoms before, one and three months after the intervention that reflected upon relieving uterine prolapse degree. Conclusion: women’s knowledge, the uterine prolapse symptoms and degree improved after the intervention. Recommendation: Evidence based nursing intervention as pelvic floor muscles exercise and changing lifestyle should be an integral part of the gynaecological treatment for uterine prolapse in the maternity hospitals.