Schistosomiasis is one of the most prevalent parasitic diseases in tropical and subtropical areas. Pra-ziquantel is the drug of choice but this drug showed its efficacy against adult only with no effect on juvenile stage and there was drug resistance. Natural drugs are safe. In this study phytol was used to evaluate its efficacy on schistosoma mansoni infected mice. Mice were grouped into 4 groups: Control healthy group included 15 mice, Positive control group included 15 infected animals and received no drugs. Group infected and treated with 40 mg/kg and group treated with 80 mg/kg for two successive days at 6th week post infection Serum and liver homogenate were taken for all , Bio-chemical, Hematological and Serum hepatic enzymes . This study revealed that phytol administration improved liver enzymes and decreased Tumor necrosis factor-alfa (TNF- α) in dose dependent manner.