The objective of the present study was to evaluate clinico-biochemical changes occurred in
bacterial diarrhea in Egyptian Buffalo calves less than three months old. The study was carried
out on 50 buffalo calves in El-Galaa Military farm that located in Ismailia Governorate, 40
diarrheic calves aged 55-75 days with an average body weight (35±2.5) kg were detected and
10 apparently healthy calves were kept as a control group to investigate the clinico-biochemical
profiles. E. coli mixed or co-infection of Acinetobacterbaumannii/ Iwoffiiss species with
Klebsiella and pseudomonas species were isolated from the diarrheic calves. Diarrheic calves
show signs of anorexia, weakness, dullness, staggering movement, weight loss, pale mucous
membranes with sunken eyes and dehydration. Analysis of clinical and biochemical profile of
the diarrheic calves revealed significant increase in body temperature, respiratory rate, skin
fold test, serum potassium, chloride, urea, creatinine, ALT, AST, GGT, triacylglycerols,
cortisol, CRP and CPK with significant decrease in pulse rate, serum sodium, glucose and total
protein concentrations. It could be concluded that, bacterial diarrhea has a severe negative
impact on the clinical and biochemical profile of the affected buffalo calves