Staff Members - Benha University
Evaluation of the HOXA9 and MEIS1 genes as a potential biomarker in adult acute myeloid leukemia
• 2023
Publication Information
Authors
Amira M. N. Abdelrahman1
, Fetnat Mahmoud Tolba1
, Howyda Mohamed Kamal1
, Mona S. Abdellateif2
,
Heba Abdelmoneim Ahmed1* and Naglaa M. Hassan3
Keywords
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publication.type
Local
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Supplementary Materials
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Abstract
Background Acute myeloid leukemia (AML) is a heterogeneous disorder encompassing a set of hematopoietic
tumors that develop when the myeloid precursor cells undergo disproportionate clonal proliferation. Homeobox A
9 (HOXA9) is a pioneer transcription factor in AML pathogenesis along with its cofactor myeloid ecotropic integration
site 1 (MEIS1). Our work aimed to evaluate the diferent expression levels of HOXA9 and MEIS1 genes and their diagnostic and prognostic signifcance in adult Egyptian patients with de novo AML. The study was carried out on 91 de
novo AML Egyptian patients and 41 healthy individuals. Bone marrow samples were obtained from both patients and
controls and then tested by reverse transcription-quantitative polymerase chain reaction to assess the mRNA expression in the studied genes.
Results HOXA9 and MEIS1 gene expression levels were signifcantly elevated in AML patients compared to controls
(p
tumors that develop when the myeloid precursor cells undergo disproportionate clonal proliferation. Homeobox A
9 (HOXA9) is a pioneer transcription factor in AML pathogenesis along with its cofactor myeloid ecotropic integration
site 1 (MEIS1). Our work aimed to evaluate the diferent expression levels of HOXA9 and MEIS1 genes and their diagnostic and prognostic signifcance in adult Egyptian patients with de novo AML. The study was carried out on 91 de
novo AML Egyptian patients and 41 healthy individuals. Bone marrow samples were obtained from both patients and
controls and then tested by reverse transcription-quantitative polymerase chain reaction to assess the mRNA expression in the studied genes.
Results HOXA9 and MEIS1 gene expression levels were signifcantly elevated in AML patients compared to controls
(p