Purpose: Find out advantages & efficacy of Platelet Rich Plasma versus conventional ordinary dressing in management of diabetic foot wound. Background: Diabetic foot wound treatment places a considerable strain on the medical system, with long waiting time for healing in the public hospital system. Platelet Rich Plasma allows efficient treatment of many patients with hemostatic, ≤Patients and methods: This prospective study was conducted on 80 diabetic feet wounds; Patients were arranged into two groups; Group A: Conventional ordinary dressing (N=40 (50%)), Group B: PRP dressing (N=40 (50%)). Follow-up period was for 12-weeks. Results: The estimated time of wound healing was 12 weeks for (82.5%) in group (A) and (97.5%) in group (B); PRP group had shown to be more effective with less complications; less infection, exudates, pain and failed healing; 17.5%, 12.5%, 32.5% and 2.5% Vs 27.5%, 42.5%, 62.5% and 17.5% in group (B) respectively with P-Value ≤ 0.001. There was highest healing rate for both groups at the 4th week but more better for PRP group (B); 0.89 ± 0.13 cm²/week Vs 0.49 ± 0.11 cm²/week in group (A). Conclusions: The use of PRP in therapeutic processes has been given noticeable advances over recent years in tissue regeneration therapy. PRP is a powerful weapon for treating chronic wounds and very promising for diabetic foot wounds; as PRP provides healing, reduces infection rates and exudates, besides it reduces amputation rates. Key words: Diabetic Foot Wounds, Platelet Rich Plasma, Conventional Ordinary Dressing, Healing Outcomes.