Objective: We are trying to check the efficacy and safety of two operative techniques designed for treating morbid obese patients, Laparoscopic Sleeve Gastrectomy (LSG) and Laparoscopic Roux-en-Y Gastric Bypass (LRYGB).

Patients & Methods: The study includes 72 morbidly obese patients, divided into two groups; group A, 40 patients (55.5%) treated by LSG, while group B, 32 patients (44.5%) managed by LRYGB. Operations completed according to the rules of laparoscopic surgery. Collected operative data included operative time, intraoperative complications, PO complications, ICU, and hospital stay. All patients were monitored throughout the 1st two PO years at 3rd, 6th, 12th and 24th PO months.

Results: There is a significant difference between both groups about operative time. The rates of early PO complications were higher in LRYGB than LSG group. Both groups showed a significant weight loss at the 1st 12 PO months. The mean BMI dropped from 39.5±3.03 kg/m2 to 33.10±3.56 kg/m2 Among LSG patients, compared with 40.18±3.18 kg/m2 to 30.23±2.64 kg/ between LRYGB patients. However, at the end of 2nd PO year, no difference in patients’ weight, BMI, %EWL or EBMIL in both groups. At the end of 1st PO year, a dramatic improvement in both groups about frequency and severity of associated comorbidities except for GERD. At the end of 2nd PO year, all comorbidities showed prominent remission among patients of LSG group. Patients of LRYGB showed complete resolution of T2DM, OSAS, and depression.

Conclusion: Both LSG and LRYGB are safe bariatric surgical procedures that deliver convenient outcomes in weight loss and resolution of most obesity-associated comorbidities.

Keywords: Laparoscopic Sleeve Gastrectomy, Roux-en-Y gastric bypass. BMI, morbid obesity.